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Systemic adverse reactions are unlikely from topical administration

In preclinical studies of breast cancer cell lines, inhibition of PAR-1 resulted in a significant reduction in tumor growth and metastatic lesions [135137] (Figure 4)

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These differ in their suitability for specific tissues, the extent to which tissue samples may be expanded in culture, the degree to which cultures reflect tissue organization and differentiation, the length of time that cultures may be maintained before passage and the cost of the required media (Fig